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KMID : 1137020240350010003
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Journal of Gynecologic Oncology
2024 Volume.35 No. 1 p.3 ~ p.3
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Adherence of PARP inhibitor for frontline maintenance therapy in primary epithelial ovarian cancer: a cross-sectional survey
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Kim Ji-Hyun
Lee Yu-Mi
Kim Da-Young
Kim Si-Nae
Seo Sang-Soo
Kang Sok-Bom
Park Sang-Yoon
Lim Myong-Cheol
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Abstract
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Objective: To identify the adherence rate to poly (ADP-ribose) polymerase (PARP) inhibitors and identify factors contributing to the deterioration of adherence at our institution.
Methods: The adherence rate to PARP inhibitors was calculated using self-reported Adherence to Refills and Medications Scale questionnaires from a cross-sectional survey. Multivariable logistic regression analysis was performed to identify the factors that affected adherence.
Results: Of the 131 respondents, 32 (24.4%) showed non-adherence to PARP inhibitors. In the multivariable logistic regression analysis, unemployed or retired status (odds ratio [OR]=4.878; 95% confidence interval [CI]=1.528?15.572; p=0.008), patients receiving niraparib (OR=3.387; 95% CI=1.283?8.940; p=0.014), and a lower score on the quality-of-life assessment (EORTC-QLQ-OV28), which reflects a better quality of life (QOC) with a lower symptom burden (OR=1.056; 95% CI=1.027?1.086; p<0.001) were associated with high adherence to PARP inhibitors.
Conclusion: Approximately one-fourth of patients with ovarian cancer are non-adherent to PARP inhibitors as maintenance treatment for newly diagnosed advanced ovarian cancer. The occupational status, type of PARP inhibitor, and QOC may affect adherence to PARP inhibitors.
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KEYWORD
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Ovarian Cancer, PARP Inhibitor, Compliance, Survey
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